Senior Manager, Statistical Programming

Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next‑generation precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, the company leverages the genetic principle of synthetic lethality to identify and develop therapies that target critical cancer pathways, including tumor‑suppressor gene loss and mechanisms that enable cancer cells to evade immune killing. The Tango labs and offices are located at 201 Brookline Avenue in the Fenway area of Boston, Massachusetts. This is a Hybrid/Flexible role. Summary Tango has an exciting opportunity to join its growing Biometrics team as a Senior Manager, Statistical Programming, reporting to the Senior Director of Statistical Programming. The Senior Manager will lead study‑specific statistical programming activities, maintain programming infrastructure, and ensure compliance with SOPs to deliver high‑quality, timely outputs. Your Role Lead statistical programming activities for clinical trials and studies, ensuring high‑quality and timely deliverables for CSR, publications, presentations, and reports for health authority submissions, clinical data review, and ad hoc analysis. Develop, validate, and maintain analysis datasets (SDTM, ADaM), tables, listings, figures, and TLFs in accordance with regulatory guidelines and internal standards. Review key clinical study or program documents. Perform complex statistical analyses and simulations using SAS or R to support clinical trial design and data interpretation; manage macro libraries and templates for efficient preparation, processing, analysis, and validation of clinical data. Provide expertise in statistical programming for regulatory submissions (e.g., FDA, EMA), including electronic submission standards (eCTD). Collaborate with biostatisticians, data managers, and cross‑functional team members to define programming strategies and requirements, establish project timelines, and perform statistical analyses. Author or review SDTM and ADaM specifications to ensure compliance with CDISC standards. Author and review statistical analysis‑related SOPs. Stay current with industry trends, best practices, and emerging technologies in statistical programming and data analysis. Perform additional duties and responsibilities as required. What You Bring Bachelor’s or master’s degree in statistics, life sciences, computer science, or a related field with at least 8 years of statistical programming experience. Experience in oncology preferred. Solid understanding of industry standards applicable to clinical study data and regulatory reporting requirements, including eCTD and CDISC implementation. Expert level in SAS programming (Base, Macro, STAT, GRAPH, SQL) is essential; experience delivering complex programming assignments, macros, and analyses. Experience with R is desirable. Extensive experience in clinical studies, including programming and validation of SDTM and ADaM datasets, tables, listings, and figures. Expertise in the requirements and technology to support electronic submissions. Experience with BLA, NDA/sNDA submissions to FDA/EMA preferred. Strong analytical and communication skills. We are an equal‑opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. Salary range: $157,600—$236,400 USD #J-18808-Ljbffr